十万个冷笑话2

百林科兰州层析填料全新蛋白A及羟基磷灰石B15智能车间正式落成投运，标志着百林科在制药核心耗材"国产替代"道路上，又一次从技术突破到大规模、高质量稳定供应的关键跨越。以"筑基智能制造，层析健康未来"为主题的B15填料自动化产线投运启动活动，在兰州新区政府的大力支持下成功举行。百林科管理团队与生物制药产业链的关键行业伙伴，共同见证新车间及自动化产线正式投入运行。    Filmmaker Anil Sharma's association with Dharmendra and the Deol family goes back a long way. He had directed the late actor in Hukumat (1987), which went on to be one of the biggest blockbusters of the filmmaker's career. Together, they delivered more hits such as Elaan-E-Jung (1989), Farishtay (1991) and Apne (2007). Filmfare caught up with Sharma, who opened his heart about this bond with Dharmendra.Excerpts:     What kind of an impact did Dharamji have on your life and career?     My entire career exists because of him. The first star I ever saw on the big screen was Dharmendra. When I became an assistant director, I worked with him on The Burning Train (1980). And the biggest blockbuster of my life, my first blockbuster Hukumat was also with him. We also did Elaan-E-Jung, Farishtay (1991) and Tahalka (1992), and all four were hits.          I worked with his son Sunny Deol on Gadar: Ek Prem Katha (2001). I produced Policewala Gunda (1995) and directed Ab Tumhare Hawale Watan Saathiyo (2004) with Bobby Deol. My film Apne had all the three Deols in it. Then there were The Hero: Love Story of a Spy (2003) and Singh Saab The Great (2013). My whole life has been spent working with the Deols and most with Dharamji. I consider myself fortunate to have worked with this family and Dharmendra. He was a legend, an era by himself . People love him so much because he too loved them in equal measure.     Go on...     Dharmendra was a young man from Sahnewal... He would stand before the Frontier Mail train and say, 'Frontier, please take me to Bombay.' And truly, Dharmendra became the film industry. He would have 6–7 releases in a single year, and all of them were hits… Today, if an actor gives even three hits in a year, he’ll run around with a sword, ready to conquer the entire country.     Dharmendra ji delivered massive blockbusters that no hero today has ever seen on that scale. It was not just action films that worked. He did films like Anupama, Chupke Chupke, Naya Zamana, Mera Gaon Mera Desh, Pratigya, Yaadon Ki Baarat, Hukumat. He had such a range! All these were hit films. And he was so handsome… It felt like God crafted him with his own hands, and then broke the mould forever. He was what you truly call, 'a Greek God'. Today we loosely call many heroes 'Greek God' but the real Greek God was Dharmendra.          It is said that he never increased his fee even after delivering blockbusters...He had multiple hits releasing at the same time. When he watched Hukumat, he liked it a lot. His payment terms used to be that some money was given during production and the rest upon release. So, he told me, 'Anil, you've made such a wonderful film, I'm waving off my entire balance fee.' He would waive off his remaining payment if you made a good film. He had no attachment to money; his attachment was only to good cinema.     How was your last meeting with him?     It was a couple of months ago. He asked me about the films I was working on. He then said that he wants to do such a film that the world will watch in awe and asked me to find a role for him. He said, "Camera meri mehbooba hai, aur mujhe miss kar rahi hai..." (Camera is my beloved, and she is missing me) I'm missing her too and I have to go back to her. He actually had a film ready to release and in the last couple of years, he had done films, and he had such passion even at the age of 89. He would tell me, "Just watch, I’ll do such good work that the world will watch… you’ll see what I’ll do. You’ll see." It felt like he was the same little boy from Sahnewal.                                                                 View this post on Instagram          A post shared by Anil Sharma (@anilsharma_dir)               How was Dharmendra as a person when the cameras stopped rolling?      Dharamji never realised how big his stardom and influence was. We would tell him that you are such a big star and he would say, "I am nothing...I am just a farmer, a man of the soil." In fact, the entire Deol family is like that. They genuinely believe they are still new and have a lot more to achieve. Dharam ji once said that he worked only for the people and their love. He came to be a part of the film industry, and he didn’t just become a part of it, he became the film industry itself.     Tell us about Sher, Dharmendra's shelved James Bond style spy thriller...     Sher goes back to 1988. I wanted to make a James Bond–style film. Recently the poster suddenly resurfaced, and everyone was shocked seeing Dharmendra with such a fantastic, powerful physique. I was a big fan of Bond films, because what does a Bond film need? Personality, handsomeness, wit, romance in the eyes, action prowess, intelligence, and Dharam ji had every single one of those qualities. But somehow, the film couldn’t get made. Hukumat hadn’t released yet at that time and I had signed Sher during Hukumat itself. The producer ran into some issues. If the film had been made, it would have been something remarkable in Dharamji’s career. I still have the script with me. Even now, people tell me to make it with Sunny Deol. I haven’t thought about it yet, but yes, I’ll see, and maybe I will think about it again.     What do you want people to remember most about Dharmendra and his legacy?     He was a genuinely good human being who knew how to love. I used to ask him what defines a good actor and he always said that a good actor is first a good person. If today’s actors understand just this one thing, they’ll automatically become better actors. If you’re a good person, you can play a bad man, you can play a worthless man, you can play an average man. His goodness, and the way he showered love on people, these two qualities were truly special about him. And that is exactly how he will always be remembered. He is a legend and legends never die, they remain immortal.     Also Read: Exclusive: When Esha Deol Called Dharmendra and Hema Malini Excellent Babysitters。

图1：百林科管理层（从左至右：副总裁张天勇、创始人兼董事长陈志、首席执行官张铮、副总裁王智）共同为B15填料自动化产线投运启幕全新的B15 蛋白A及羟基磷灰石车间的落成投运，在百林科独特且稳定的生产工艺上结合了全自动化控制，是百林科持续推进层析填料产业化和智能制造建设的重要一步。作为兰州新区生物医药产业布局的一部分，百林科兰州基地经过持续建设，已逐步形成覆盖研发、生产及质量管理等环节的产业化体系。此次新产线投运，将进一步提升基地自动化生产、规模化制造及供应保障能力，为层析填料业务持续发展提供更加坚实的制造支撑。

图2：启幕仪式在关键行业伙伴的见证及兰州新区政府的大力支持下举行B15车间正式投运，智造能力再升级B15车间主要布局蛋白A全自动偶联生产线及羟基磷灰石生产线，是百林科进一步完善层析填料自动化生产体系的重要布局。目前，百林科兰州基地已建成1条500L及3条1000L全品类层析填料自动化生产线，以及一条在建的硬胶自动化生产线。搭配一条全自动灌装线, 实现智能制造全流程贯穿，有效提升效率与批次一致性，整体自动化率达到90%。其中，琼脂糖葡聚糖层析填料年产能可达 25万升, 羟基磷灰石年产能达10吨，并配备3000余平方米甲类防爆厂房，以及GMP标准D级洁净分装区及仓储区，为层析填料规模化生产提供制造基础。百林科创始人兼董事长陈志表示，自兰州填料智能制造基地建设之初，百林科就希望将其打造成为集研发、与产业化于一体的层析填料基地。B15车间的落成投运，不仅是生产设施的进一步完善，更是百林科持续提升制造能力和供应保障能力的重要一步。"智能制造的核心并不只是提高生产效率，更重要的是建立更加稳定、可控的生产体系，为客户提供稳定的产品和供应保障。"陈志表示。未来，百林科将持续推动产品、技术与制造能力协同发展，与客户共同推动国产层析填料从产品替代走向更广泛的规模化应用。

图3：B15车间内的蛋白A全自动偶联生产线全品类布局持续完善，产业化能力进一步提升B15新产线的投入运行，也进一步完善了百林科兰州基地的层析填料产品及生产布局。

B | 目前，百林科层析填料产品已覆盖葡聚糖琼脂糖软胶、聚合物硬胶、羟基磷灰石等多个产品类别，涵盖离子交换、亲和、疏水、过滤、多模式、反向等层析原理，形成百余种细分产品。此次B15车间投运，将进一步增强蛋白A、羟基磷灰石等产品的规模化生产能力，并与基地现有自动化生产线形成协同，推动百林科层析填料从多产品布局向更加完善的全品类产业化体系发展。与此同时，兰州基地通过DCS自动化控制系统及GDS系统，对生产过程进行数字化管理与安全控制，实现关键工艺参数的实时监测与自动控制，持续提升生产流程的标准化、数字化和自动化水平。2024年，兰州基地还获评甘肃省"数字化车间"。

图4：百林科兰州层析填料智造基地屡获“数字化车间”等殊荣以智能制造支撑国产层析填料发展随着生物医药产业持续发展，层析填料作为生物制药下游纯化环节的重要材料，其产品性能、质量稳定性和供应能力受到越来越多关注。

C | 对于国产层析填料而言，从产品研发走向规模化应用，不仅需要持续突破核心技术，也需要稳定、可靠的产业化制造能力。B15车间的正式投运，正是百林科围绕这一目标持续投入的重要成果。未来，百林科将持续推进核心技术研发、产品创新与智能制造能力建设，不断完善层析填料产品与产业化布局，以更加稳定、高效的制造能力，为生物制药客户提供高品质、高可靠性的层析填料及生物工艺解决方案。筑基智能制造，层析健康未来。赋能生物技术，通达无限可能。

D |